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PLoS One. 2012;7(12):e51691. doi: 10.1371/journal.pone.0051691. Epub 2012 Dec 13.

Prostatic stones: evidence of a specific chemistry related to infection and presence of bacterial imprints.

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Laboratoire de Physique des Solides, Université Paris Sud, Centre National de la Recherche Scientifique, Orsay, France.


Prostatic stones are a common condition in older men in industrialized countries. However, aging appears not to be the unique pathogenesis of these calcifications. Our morpho-constitutional investigation of 23 stone samples suggested that infection has a significant role in the lithogenic process of prostate calcifications, even without detection of infection by clinical investigation. Most stones (83%) showed bacterial imprints and/or chemical composition, suggestive of a long-term infection process. Chronic infection may induce persistent inflammation of the tissue and secondarily, a cancerization process within a few years. Thus, the discovery of prostate calcifications by computerized tomodensitometry, for example, might warrant further investigation and management to search for chronic infection of the prostate gland.

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