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Endocrine. 2013 Oct;44(2):391-401. doi: 10.1007/s12020-012-9863-0. Epub 2012 Dec 28.

Improvement in insulin resistance and favourable changes in plasma inflammatory adipokines after weight loss associated with two months' consumption of a combination of bioactive food ingredients in overweight subjects.

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1
Department of Applied Health Sciences, Section of Human Nutrition and Dietetics, Faculty of Medicine, University of Pavia, Azienda di Servizi alla Persona di Pavia, Servizio Endocrino Nutrizionale, Istituto di Riabilitazione "Santa Margherita", Via Emilia 12, Pavia, Italy, mariangela.rondanelli@unipv.it.

Erratum in

  • Endocrine. 2013 Oct;44(2):402. Edda, Cava [corrected to Cava, Edda]; Maddalena, Paolini [corrected to Paolini, Maddalena]; Luciano, Scavone [corrected to Scavone, Luciano]; Paola, Ceccarelli [corrected to Ceccarelli, Paola]; Emanuela, Castellaneta [corrected to Castellaneta, Emanuela];.

Abstract

This randomized, double blind, placebo-controlled, 8 week trial assessed the efficacy on metabolic changes produced by a consumption of a combination of bioactive food ingredients (epigallocatechin gallate, capsaicins, piperine and L-carnitine) versus a placebo, as part of a therapeutic 'lifestyle change' diet, in 86 overweight subjects. Forty-one patients (2/14 F/M; age 43.7 ± 8.5; BMI 30.3 ± 3.5 kg/m(2)) were randomized to the supplemented group and 45 (29/16; age 40.7 ± 10.2; BMI 30.0 ± 2.7) to the control group. We observed that consumption of the dietary supplement was associated with a significantly greater decrease in insulin resistance, assessed by homostasis model assessment (p < 0.001), leptin/adiponectin ratio (p < 0.04), respiratory quotient (p < 0.008). LDL-cholesterol levels (p < 0.01). Moreover, statistically significant differences were recorded between the two groups in relation to urinary norepinephrine levels (p < 0.001). Leptin, ghrelin, C-reactive protein decreased and resting energy expenditure increased significantly in the supplemented group (p < 0.05, 0.03, 0.02 and 0,02 respectively), but not in the placebo group; adiponectin decreased significantly in the placebo group (0.001) but not in the supplemented group, although no statistical significance between the groups was elicited. BMI, fat mass (assessed by DXA) and vascular endothelial growth factor significantly decreased, whilst the resting energy expenditure/free fat mass significantly increased in both groups. In general, a greater change was recorded in the supplemented group compared to the placebo, although no statistically significant difference between the two groups was recorded. These results suggest that the combination of bioactive food ingredients studied might be useful for the treatment of obesity-related inflammatory metabolic dysfunctions.

PMID:
23271695
PMCID:
PMC3790246
DOI:
10.1007/s12020-012-9863-0
[Indexed for MEDLINE]
Free PMC Article

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