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Kidney Int. 2013 Jan;83(1):6-9. doi: 10.1038/ki.2012.369.

Hypertension-misattributed kidney disease in African Americans.

Author information

1
Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Rambam Health Care Campus, Haifa, Israel. skorecki@tx.technion.ac.il

Abstract

Lipkowitz et al. extend the African American Study of Kidney Disease and Hypertension to the level of genetic epidemiology, in a case-control study design. Analysis of genotypes at the APOL1 kidney disease risk region supports a paradigm shift in which genetic risk is proximate to both kidney disease and hypertension. The findings mandate urgency in clarifying mechanisms whereby APOL1 region risk variants interact with environmental triggers to cause progressive kidney disease accompanied by dangerous hypertension.

PMID:
23271482
DOI:
10.1038/ki.2012.369
[Indexed for MEDLINE]
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