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Rheumatol Int. 2014 Jan;34(1):145-7. doi: 10.1007/s00296-012-2640-9. Epub 2012 Dec 28.

Cryoglobulinemic vasculitis in systemic sclerosis successfully treated with mycophenolate mofetil.

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  • 1School of Medicine, Institute of Rheumatology, University of Belgrade, Resavska 69, 11000, Belgrade, Serbia,


Cryoglobulinemic vasculitis is extremely rare in patients with systemic sclerosis (SSc). So far, only two cases of cryoglobulinemic vasculitis in SSc were described in the literature. This report is about a patient with SSc and secondary Sjőgren's syndrome, who developed typical clinical features of small-vessel vasculitis, including arthritis, purpura, microhaematuria, gangrene of fingers, and toes and myocardial ischemia, in the presence of mixed cryoglobulinemia, ANA, rheumatoid factor, and anti-SSA/Ro antibodies. Symptoms and signs of vasculitis worsened despite initial treatment with corticosteroids and cyclophosphamide, but improved significantly when mycophenolate mofetil was used instead cyclophosphamide.

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