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Mar Drugs. 2012 Dec 27;11(1):33-9. doi: 10.3390/md11010033.

Isolation, characterization, and bioactivity evaluation of 3-((6-methylpyrazin-2-yl)methyl)-1H-indole, a new alkaloid from a deep-sea-derived actinomycete Serinicoccus profundi sp. nov.

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1
Luxembourg Public Research Center for Health (CRP-SANTE), 84 Val Fleuri, Luxembourg L-1526, Luxembourg. xianwen.yang@crp-sante.lu

Abstract

One new alkaloid, 3-((6-methylpyrazin-2-yl)methyl)-1H-indole (1) was obtained from the deep-sea actinomycete Serinicoccus profundi sp. nov., along with five known compounds (2-6). Their structures were determined on the basis of detailed analysis of the 1D and 2D NMR as well as MS data. The new indole alkaloid displayed weak antimicrobial activity against Staphylococcus aureus ATCC 25923 with an MIC value of 96 μg/mL. It showed no cytotoxicity on a normal human liver cell line (BEL7402) and a human liver tumor cell line (HL-7702).

PMID:
23271423
PMCID:
PMC3564155
DOI:
10.3390/md11010033
[Indexed for MEDLINE]
Free PMC Article
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