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Int J Mol Sci. 2012 Dec 27;14(1):496-514. doi: 10.3390/ijms14010496.

Chemical constituents from Andrographis echioides and their anti-inflammatory activity.

Author information

  • 1Department of Chemistry, National Cheng Kung University, Tainan 70101, Taiwan. tswu@mail.ncku.edu.tw.

Abstract

Phytochemical investigation of the whole plants of Andrographis echioides afforded two new 2'-oxygenated flavonoids (1) and (2), two new phenyl glycosides (3) and (4), along with 37 known structures. The structures of new compounds were elucidated by spectral analysis and chemical transformation studies. Among the isolated compounds, (1-2) and (6-19) were subjected into the examination for their iNOS inhibitory bioactivity. The structure-activity relationships of the flavonoids for their inhibition of NO production were also discussed.

PMID:
23271366
PMCID:
PMC3565277
DOI:
10.3390/ijms14010496
[PubMed - indexed for MEDLINE]
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