Format

Send to

Choose Destination
See comment in PubMed Commons below
Int J Environ Res Public Health. 2012 Dec 27;10(1):107-43. doi: 10.3390/ijerph10010107.

Mouse models for efficacy testing of agents against radiation carcinogenesis—a literature review.

Author information

1
Department of Environmental Health Sciences, University of California, Los Angeles, 650 Charles E. Young Dr. South, CHS 71-295, Los Angeles, CA 90095, USA. yrivin@ucla.edu

Abstract

As the number of cancer survivors treated with radiation as a part of their therapy regimen is constantly increasing, so is concern about radiation-induced cancers. This increases the need for therapeutic and mitigating agents against secondary neoplasias. Development and efficacy testing of these agents requires not only extensive in vitro assessment, but also a set of reliable animal models of radiation-induced carcinogenesis. The laboratory mouse (Mus musculus) remains one of the best animal model systems for cancer research due to its molecular and physiological similarities to man, small size, ease of breeding in captivity and a fully sequenced genome. This work reviews relevant M. musculus inbred and F(1 )hybrid animal models and methodologies of induction of radiation-induced leukemia, thymic lymphoma, breast, and lung cancer in these models. Where available, the associated molecular pathologies are also included.

PMID:
23271302
PMCID:
PMC3564133
DOI:
10.3390/ijerph10010107
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
    Loading ...
    Support Center