Abstract
In the present study, we evaluated the anti-inflammatory effect of 4-methoxy-5- hydroxycanthin-6-one (CAN), a natural alkaloid isolated from Picrasma quassioides. CAN significantly inhibited the production of NO and the release of TNF-α induced by LPS in macrophage RAW 264.7. Western blot showed that CAN can downregulate the expression of iNOS protein. After oral administration, CAN (3, 9, and 27 mg/kg) reduced the development of carrageenan-induced paw edema and complete Freund's adjuvant (CFA)-induced chronic arthritis in rats. The observed results indicated that pre-treatment with CAN might be an effective therapeutic intervention against inflammatory diseases including chronic arthritis.
Copyright © 2012 Elsevier GmbH. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents / isolation & purification
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Anti-Inflammatory Agents / pharmacology
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Anti-Inflammatory Agents / therapeutic use*
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Arthritis / chemically induced
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Arthritis / drug therapy*
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Carrageenan
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Cell Line
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Drug Evaluation, Preclinical
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Drugs, Chinese Herbal / pharmacology
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Drugs, Chinese Herbal / therapeutic use
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Edema / chemically induced
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Edema / drug therapy*
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Indoles / pharmacology
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Indoles / therapeutic use*
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Lipopolysaccharides
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Macrophages / drug effects
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Macrophages / metabolism
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Mice
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Naphthyridines / pharmacology
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Naphthyridines / therapeutic use*
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Nitric Oxide / metabolism
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Phytotherapy
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Picrasma / chemistry*
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Rats
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Rats, Sprague-Dawley
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Tumor Necrosis Factor-alpha / metabolism
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Xylenes
Substances
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Anti-Inflammatory Agents
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Drugs, Chinese Herbal
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Indoles
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Lipopolysaccharides
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Naphthyridines
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Tumor Necrosis Factor-alpha
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Xylenes
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Nitric Oxide
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Carrageenan
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nigakinone