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Knee. 2013 Aug;20(4):277-80. doi: 10.1016/j.knee.2012.12.001. Epub 2012 Dec 24.

Platelet rich plasma use in allograft ACL reconstructions: two-year clinical results of a MOON cohort study.

Author information

1
Department of Orthopaedics, OSU Sports Medicine, Sports Health and Performance Institute, The Ohio State University, Columbus, OH 43221, USA.

Abstract

BACKGROUND:

Platelet rich plasma has been promoted as a biologic agent to enhance tissue healing. As a concentration of autologous growth factors, it has gained increased use in musculoskeletal applications.

METHODS:

The purpose of this study was to evaluate the effect of intra-operative PRP on patient-reported outcomes 2 years after ACL reconstruction with tibialis anterior allograft. Fifty patients who underwent allograft ACL reconstruction with intra-operative application of PRP to the graft were matched with 50 allograft ACL -reconstructions without PRP use. The same surgeon performed all procedures with identical technique. Two year patient-reported outcomes including KOOS, IKDC, and Marx activity scores were obtained. Effusions in the immediate post-operative period, post-operative complications, and any subsequent procedures were also recorded.

RESULTS:

There was no difference between the groups with respect to additional surgeries or complications in the first 2 years after reconstruction. Decreased effusions at 10±4 days were noted in the PRP group, but this difference disappeared by 8±4 weeks. No differences in patient-reported outcomes were noted in the 58 patients with two-year outcome data.

CONCLUSION:

The study demonstrated that although PRP application in tibialis allograft ACL reconstructions appeared safe; clinical benefit was minor and short-term. No differences in patient-reported outcomes or number of additional surgeries at 2 years were noted.

LEVEL OF EVIDENCE:

Level III - retrospective comparative study.

PMID:
23270598
PMCID:
PMC4170685
DOI:
10.1016/j.knee.2012.12.001
[Indexed for MEDLINE]
Free PMC Article

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