Format

Send to

Choose Destination
Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):725-30. doi: 10.1073/pnas.1214718110. Epub 2012 Dec 26.

Neuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors through extracellular coupling.

Author information

1
Biozentrum, University of Basel, 4056 Basel, Switzerland.

Abstract

Despite the pivotal functions of the NMDA receptor (NMDAR) for neural circuit development and synaptic plasticity, the molecular mechanisms underlying the dynamics of NMDAR trafficking are poorly understood. The cell adhesion molecule neuroligin-1 (NL1) modifies NMDAR-dependent synaptic transmission and synaptic plasticity, but it is unclear whether NL1 controls synaptic accumulation or function of the receptors. Here, we provide evidence that NL1 regulates the abundance of NMDARs at postsynaptic sites. This function relies on extracellular, NL1 isoform-specific sequences that facilitate biochemical interactions between NL1 and the NMDAR GluN1 subunit. Our work uncovers NL1 isoform-specific cis-interactions with ionotropic glutamate receptors as a key mechanism for controlling synaptic properties.

PMID:
23269831
PMCID:
PMC3545745
DOI:
10.1073/pnas.1214718110
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center