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Exp Gerontol. 2013 Oct;48(10):1085-90. doi: 10.1016/j.exger.2012.12.008. Epub 2012 Dec 23.

Dietary restriction supports peripheral nerve health by enhancing endogenous protein quality control mechanisms.

Author information

1
Department of Neuroscience, College of Medicine, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, United States.

Abstract

The peripheral nervous system (PNS) comprises of an extensive network of connections that convey information between the central nervous system (CNS) and peripheral organs. Long myelinated nerve fibers are particularly susceptible to age-related changes, as maintenance of the insulating glial membrane requires extensive synthesis and processing of many proteins. In rodent models, peripheral demyelination caused by genetic risk factors or by normal aging are attenuated by intermittent fasting (IF) or calorie restriction (CR) supporting a role for dietary intervention in preserving neural function. This review will summarize recent studies examining mechanisms by which life-long CR or extended IF supports peripheral nerve health.

KEYWORDS:

Autophagy; Chaperones; Demyelination; Glia; Myelin; Neuropathy; Proteasome; Protein aggregation; Schwann cell

PMID:
23267845
PMCID:
PMC3652890
DOI:
10.1016/j.exger.2012.12.008
[Indexed for MEDLINE]
Free PMC Article

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