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Bioarchitecture. 2012 Nov-Dec;2(6):200-3. doi: 10.4161/bioa.22726.

BioArchitecture: the organization and regulation of biological space.

Author information

1
School of Medical Sciences, University of New South Wales, Sydney, Australia. p.gunning@unsw.edu.au

Abstract

BioArchitecture is a term used to describe the organization and regulation of biological space. It applies to the principles which govern the structure of molecules, polymers and mutiprotein complexes, organelles, membranes and their organization in the cytoplasm and the nucleus. It also covers the integration of cells into their three dimensional environment at the level of cell-matrix, cell-cell interactions, integration into tissue/organ structure and function and finally into the structure of the organism. This review will highlight studies at all these levels which are providing a new way to think about the relationship between the organization of biological space and the function of biological systems.

KEYWORDS:

actin; cytoskeleton; intermediate filaments; isoform sorting; microtubules; nuclear structure; protein folding

PMID:
23267413
PMCID:
PMC3527313
DOI:
10.4161/bioa.22726
[Indexed for MEDLINE]
Free PMC Article
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