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J Cell Biol. 2012 Dec 24;199(7):1057-66. doi: 10.1083/jcb.201207180.

Cab45 is required for Ca(2+)-dependent secretory cargo sorting at the trans-Golgi network.

Author information

1
Max Planck Institute for Biochemistry, 82152 Martinsried, Germany.

Abstract

Ca(2+) import into the lumen of the trans-Golgi network (TGN) by the secretory pathway calcium ATPase1 (SPCA1) is required for the sorting of secretory cargo. How is Ca(2+) retained in the lumen of the Golgi, and what is its role in cargo sorting? We show here that a soluble, lumenal Golgi resident protein, Cab45, is required for SPCA1-dependent Ca(2+) import into the TGN; it binds secretory cargo in a Ca(2+)-dependent reaction and is required for its sorting at the TGN.

PMID:
23266954
PMCID:
PMC3529532
DOI:
10.1083/jcb.201207180
[Indexed for MEDLINE]
Free PMC Article

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