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Clin Genitourin Cancer. 2013 Jun;11(2):73-7. doi: 10.1016/j.clgc.2012.11.002. Epub 2012 Dec 23.

A clinical review of small-cell carcinoma of the urinary bladder.

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Department of Internal Medicine, Fairview Hospital, Cleveland Clinic Hospitals, Cleveland, OH 44111, USA.


Small-cell carcinoma of the urinary bladder is a rare and aggressive type of bladder cancer that has a poor prognosis. The incidence has been gradually increasing because of the aging population. Owing to its rarity there are no available treatment guidelines. Several retrospective studies and 1 prospective study have provided some insight into therapy for this disease. A multimodal approach that includes chemotherapy, local radiation therapy, and definitive surgery in resectable cases appears to be an optimal management approach.

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