Format

Send to

Choose Destination
See comment in PubMed Commons below
Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Feb;115(2):218-23. doi: 10.1016/j.oooo.2012.09.084. Epub 2012 Dec 20.

Influence of pathologic complete response to neoadjuvant chemotherapy on long-term survival of patients with advanced head and neck squamous cell carcinoma.

Author information

1
State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, People's Republic of China.

Abstract

OBJECTIVE:

The aim of this study was to analyze whether pathologic complete response (PCR) to neoadjuvant chemotherapy (NAC) affected long-term survival in advanced head and neck squamous cell carcinoma (HNSCC) patients.

MATERIALS:

All patients with advanced HNSCC were previously untreated and underwent NAC followed by surgery. The 5-year overall survival, disease-free survival, local control rate, and reasons for treatment failure were analyzed.

RESULTS:

A total of 101 cases were included, and the response rate to NAC was 67.3%, including 17 patients (16.8%) who achieved PCR. The 5-year overall survival (OS) of the PCR group (82.4%; histologically complete response group [HCG]) was higher than that of the pathologic incomplete responder group (45.4%; histologically incomplete response group [HICG]) (P = 0.045). No statistically significant difference was noted between the two groups in terms of local recurrence and nodal recurrence, but the local control rate in HCG (88.2%) was higher than that in HICG (62.7%) (P = 0.034).

CONCLUSIONS:

Achieving PCR could improve locoregional control and long-term survival in patients with advanced HNSCC.

PMID:
23265986
DOI:
10.1016/j.oooo.2012.09.084
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center