Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Neurobiol. 2013 Aug;23(4):706-12. doi: 10.1016/j.conb.2012.11.008. Epub 2012 Dec 22.

Drink, drugs and disruption: memory manipulation for the treatment of addiction.

Author information

Behavioural and Clinical Neuroscience Institute, Department of Psychology, University of Cambridge, Downing Site, Cambridge CB2 3EB, UK.


Addiction is a complex disorder, and one characterised by the acquisition of maladaptive instrumental (drug-seeking and drug-taking) and pavlovian (cue-drug associations) memories. These memories markedly contribute to the long-term risk of relapse, so reduction of the impact of these memories on behaviour could potentially be an important addition to current therapies for addiction. Memory reconsolidation may provide such a target for disrupting well-consolidated pavlovian cue-drug memories following an extensive drug history. Reconsolidation can be disrupted either by administering amnestic drugs in conjunction with a memory reactivation session, or by updating the memory adaptively through the induction of 'superextinction'. More work is needed before these therapies are ready for translation to the clinic, but if found clinically effective memory manipulation promises a radical new way of treating addiction.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center