Format

Send to

Choose Destination
Oncoimmunology. 2012 Dec 1;1(9):1661-1663.

How imiquimod licenses plasmacytoid dendritic cells to kill tumors.

Author information

1
Institute of Cancer Research; Department of Medicine I; Comprehensive Cancer Center; Medical University of Vienna; Vienna, Austria.

Abstract

We have provided evidence for a multifaceted antitumor-function of the Toll-like receptor 7 (TLR7) agonist imiquimod, which rapidly recruits plasmacytoid dendritic cells and possibly other immune cells into tumors by inducing the secretion of CCL2 by dermal cells. Imiquimod induces pDC maturation and their conversion into cytolytic killer cells, which are capable of eliminating tumors independently from the adaptive immune system.

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center