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Oncoimmunology. 2012 Dec 1;1(9):1650-1651.

Targeting MDSCs enhance therapeutic vaccination responses against lung cancer.

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1
Department of Medicine; UCLA Lung Cancer Research Program; David Geffen School of Medicine; University of California at Los Angeles; Los Angeles, CA USA ; Molecular Gene Medicine Laboratory; Veterans Affairs Greater Los Angeles Healthcare System; Los Angeles, CA USA.

Abstract

Myeloid-derived suppressor cells (MDSCs) are important regulators of immune responses. These cells suppress the cytotoxic activities of natural killer (NK)-cell and T-cell effectors and promote tumor growth. We demonstrated that depleting MDSCs improve therapeutic responses to vaccination in a murine model of lung cancer. This approach may prove beneficial against tumors in which MDSC exert prominent immunosuppressive effects.

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