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Mult Scler. 2013 Aug;19(9):1216-8. doi: 10.1177/1352458512471875. Epub 2012 Dec 21.

Factors associated with the effectiveness of plasma exchange for the treatment of NMO-IgG-positive neuromyelitis optica spectrum disorders.

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Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.


To identify factors associated with plasma exchange response in neuromyelitis optica (NMO) spectrum disorders, the clinical and magnetic resonance imaging (MRI) features of 31 NMO-IgG-positive patients receiving plasma exchange for steroid-resistant exacerbations were analyzed. Functional improvement was observed in 65% of the patients. A lower baseline Expanded Disability Status Scale score was associated with favorable response (p = 0.040). Patients without cord atrophy had a higher success rate than patients with atrophy (p = 0.016). Levels of NMO-IgG did not differ between responders and non-responders before and after plasma exchange. In conclusion, a minimal pre-existing disability is the primary determinant of the effectiveness of plasma exchange.


Plasma exchange; neuromyelitis optica spectrum disorders; neuromyelitis optica-IgG; prognostic factors

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