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ASAIO J. 2013 Jan-Feb;59(1):93-5. doi: 10.1097/MAT.0b013e31827986e6.

Detection of carboxyhemefibrinogen and methemefibrinogen in a patient with thrombosis of a HeartMate II ventricular assist device.

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1
Department of Surgery, The University of Arizona College of Medicine, Tucson, Arizona 85724-5114, USA.

Abstract

Ventricular assist device (VAD) thrombosis is a devastating, potentially fatal complication suffered by patients requiring mechanical circulatory support. We present a patient with thrombosis of a HeartMate II VAD with concurrent hemolysis and increased carbon monoxide formation. Using a specialized thrombelastographic assay, we detected marked plasmatic hypercoagulability mediated in part by the formation of carboxyhemefibrinogen.

PMID:
23263339
DOI:
10.1097/MAT.0b013e31827986e6
[Indexed for MEDLINE]
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