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Clin Exp Nephrol. 2013 Oct;17(5):659-662. doi: 10.1007/s10157-012-0755-7. Epub 2012 Dec 21.

Evaluation of the newly proposed simplified histological classification in Japanese cohorts of myeloperoxidase-anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in comparison with other Asian and European cohorts.

Author information

1
Division of Nephrology and Dialysis, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, 2-4-20 Ohgimachi, Kita-ku, Osaka, 530-8480, Japan. muso@kitano-hp.or.jp.
2
Division of Nephrology and Dialysis, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, 2-4-20 Ohgimachi, Kita-ku, Osaka, 530-8480, Japan.
3
4th Department of Internal Medicine, Tokyo Women Medical College, Tokyo, Japan.
4
Preventive Medical Center, Department of Nephrology, International University of Health and Welfare Hospital, Tochigi, Japan.
5
Division of Internal Medicine, Shimoshizu National Hospital, Chiba, Japan.
6
Division of Pathology, Sendai Shakaihoken Hospital, Miyagi, Japan.
7
Safety Control Department, University Hospital, School of Medicine/General, Medical Education Center, Teikyo University, Tokyo, Japan.

Abstract

The prognostic value of renal biopsy in anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis is widely recognized; however, there is no consensus regarding its pathological classification. Berden et al. proposed a new classification of glomerulonephritis in ANCA-associated vasculitis (AAV) categorized into focal, crescentic, mixed, and sclerotic classes and showed its prognostic value in 100 international multicenter cohorts for 1- and 5-year renal outcomes. In order to evaluate whether this new classification has predictive value and reproducibility in Japanese AAV cases, 87 cohorts with only microscopic polyangiitis in 3 limited centers in Japan were analyzed. In addition, those from Japan, Europe (Berden's cohorts) and China were compared in a recent report.

PMID:
23263238
PMCID:
PMC3824231
DOI:
10.1007/s10157-012-0755-7
[Indexed for MEDLINE]
Free PMC Article

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