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Nanotechnology. 2013 Jan 25;24(3):035101. doi: 10.1088/0957-4484/24/3/035101. Epub 2012 Dec 21.

A simple method of labeling amyloid β with quantum dots and ingestion of the labeled amyloid β by astrocytes.

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School of Life Science, Beijing Institute of Technology, Beijing 100081, People’s Republic of China.


Steady labeling of amyloid beta (Aβ) is crucial for studying the ingestion and degradation of Aβ by astrocytes and unraveling a relevant regulation mechanism. Quantum dots (QDs) are an optimum labeling reagent for this because of their strong and steady fluorescence properties. In this paper, Aβ was labeled with QDs by a simple mixed incubation strategy, with a QD labeled Aβ complex (QDs-Aβ) being obtained. In the complex, QDs efficiently restrained the formation of β-folding and fibrils of Aβ, while the graininess, dispersivity and fluorescence properties of the QDs hardly changed. The fluorescence microscopy imaging results showed that the astrocytes could ingest the QDs-Aβ. The QDs and Aβ did not separate from each other during the ingestion process, and the Aβ could be degraded subsequently.

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