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Horm Behav. 2013 Feb;63(2):352-60. doi: 10.1016/j.yhbeh.2012.12.006. Epub 2012 Dec 21.

Vasopressin eliminates the expression of familiar odor bias in neonatal female mice through V1aR.

Author information

1
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. liz.hammock@vanderbilt.edu

Abstract

V1aR has a well established role in the neural regulation of adult mammalian social behavior. The role of V1aR in developmentally emerging social behavior is less well understood. We mapped V1aR at post-natal day 8 (P8) and demonstrate developmentally-specific expression in the neocortex and hippocampus. We tested the ability of male and female C57BL/6J mice to show orienting bias to a familiar odor at this age. We demonstrate that females, but not males, show an orienting bias for odors previously paired with the mother, which is eliminated by V1aR signaling.

PMID:
23261858
PMCID:
PMC4285782
DOI:
10.1016/j.yhbeh.2012.12.006
[Indexed for MEDLINE]
Free PMC Article

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