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Surgery. 2013 Apr;153(4):576-83. doi: 10.1016/j.surg.2012.11.018. Epub 2012 Dec 20.

Triclosan-coated sutures reduce the incidence of wound infections and the costs after colorectal surgery: a randomized controlled trial.

Author information

1
Department of Surgery, Teine-Keijinkai Hospital, Teine-ku, Sapporo, Japan. torunakamur@yahoo.co.jp

Abstract

BACKGROUND:

In colorectal surgeries, surgical site infections (SSIs) frequently cause morbidity; an incidence of up to 20% has been shown in previous studies. Recently, to prevent microbial colonization of suture material in operative wounds, triclosan-coated polyglactin suture materials with antimicrobial activity have been developed; however, their significance in colorectal surgery remains unclear. This randomized controlled trial was conducted to assess the value of triclosan-coated polyglactin sutures in colorectal surgery.

METHODS:

A total of 410 consecutive patients who had undergone elective colorectal operations were enrolled in this trial. Of those patients, the 206 in the study group underwent wound closure with triclosan-coated polyglactin 910 antimicrobial sutures, and the 204 patients in the control group received conventional wound closures with polyglactin 910 sutures.

RESULTS:

The study group and the control group were comparable regarding risk factors for SSIs. The incidence of wound infection in the study group was 9 of 206 patients (4.3%), and that in the control group was 19 of 204 patients (9.3%). The difference is statistically significant in the 2 groups (P = .047). The median additional cost of wound infection management was $2,310. The actual entire additional cost, therefore, of 9 patients in the study group was $18,370, and that of 19 patients in the control group was $60,814.

CONCLUSION:

Triclosan-coated sutures can reduce the incidence of wound infections and the costs in colorectal surgery.

PMID:
23261025
DOI:
10.1016/j.surg.2012.11.018
[Indexed for MEDLINE]

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