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Emerg Infect Dis. 2013 Jan;19(1):129-32. doi: 10.3201/eid1901.111527.

Linezolid dependence in Staphylococcus epidermidis bloodstream isolates.

Author information

1
Department of Microbiology, University of Thessaly Medical School, Larissa, Greece. pournaras@med.uth.gr

Abstract

We document linezolid dependence among 5 highly linezolid-resistant (LRSE) Staphylococcus epidermidis bloodstream isolates that grew substantially faster at 32 µg/mL linezolid presence. These isolates carried the mutations T2504A and C2534T in multiple 23S rRNA copies and 2 mutations leading to relevant amino acid substitutions in L3 protein. Linezolid dependence could account for increasing LRSE emergence.

PMID:
23260390
PMCID:
PMC3557967
DOI:
10.3201/eid1901.111527
[Indexed for MEDLINE]
Free PMC Article

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