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J Pediatr. 2013 May;162(5):918-23.e1. doi: 10.1016/j.jpeds.2012.10.062. Epub 2012 Dec 20.

Higher maternal body mass index is associated with an increased risk for later type 2 diabetes in offspring.

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1
Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, Finland. markus.juonala@utu.fi

Abstract

OBJECTIVES:

To investigate whether the body mass index (BMI) of a child's mother is associated with an increased future risk of type 2 diabetes, independent of genetic risk or childhood metabolic, behavioral, and environmental factors.

STUDY DESIGN:

The analyses were based on the Cardiovascular Risk in Young Finns Study including 1835 individuals aged 3-18 years at baseline with data on maternal BMI, childhood metabolic factors, as well as 34 newly identified type 2 diabetes susceptibility alleles. These subjects were then followed-up over 21-27 years.

RESULTS:

Maternal BMI (OR for 1-SD increase 1.54 [95% CI 1.12-2.11], P = .008) and child's systolic blood pressure (1.54 [1.01-2.35], P = .04) were significantly associated with increased odds for later type 2 diabetes, in a multivariable analysis adjusted for age, sex, type 2 diabetes genetic risk score, childhood BMI, insulin, lipids, dietary factors, socioeconomic status, and mother's age, and history of type 2 diabetes. A risk prediction model, which included maternal BMI status outperformed one which utilized only child's BMI data (area under the receiver operating characteristic curve 0.720 vs 0.623, P = .02). The inclusion of genetic risk score and other baseline risk variables did not additionally improve prediction (area under the receiver operating characteristic curve 0.720 vs 0.745, P = .40).

CONCLUSIONS:

Maternal BMI is a useful variable in determining offspring risk of developing type 2 diabetes.

PMID:
23260097
DOI:
10.1016/j.jpeds.2012.10.062
[Indexed for MEDLINE]
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