Format

Send to

Choose Destination
Org Lett. 2013 Jan 18;15(2):242-5. doi: 10.1021/ol302769r. Epub 2012 Dec 24.

Total synthesis of sedum alkaloids via catalyst controlled aza-Cope rearrangement and hydroformylation with formaldehyde.

Author information

1
Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA.

Abstract

The catalytic asymmetric aminoallylation of chiral aldehydes is developed as a new method for the catalyst controlled synthesis of syn- and anti-1,3-aminoalcohols. This methodology is highlighted in the synthesis of the sedum alkaloids (+)-sedridine and (+)-allosedridine both of which have their final carbon incorporated during closure of the piperidine ring via a hydroformylation with formaldehyde.

PMID:
23259754
PMCID:
PMC3582941
DOI:
10.1021/ol302769r
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for American Chemical Society Icon for PubMed Central
Loading ...
Support Center