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Nat Rev Mol Cell Biol. 2013 Jan;14(1):25-37. doi: 10.1038/nrm3494.

Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore.

Author information

1
Cell Biology Program, Sloan-Kettering Institute, 1275 York Ave. New York, New York 10065, USA. foleye1@mskcc.org

Abstract

In eukaryotes, chromosome segregation during cell division is facilitated by the kinetochore, a multiprotein structure that is assembled on centromeric DNA. The kinetochore attaches chromosomes to spindle microtubules, modulates the stability of these attachments and relays the microtubule-binding status to the spindle assembly checkpoint (SAC), a cell cycle surveillance pathway that delays chromosome segregation in response to unattached kinetochores. Recent studies are shaping current thinking on how each of these kinetochore-centred processes is achieved, and how their integration ensures faithful chromosome segregation, focusing on the essential roles of kinase-phosphatase signalling and the microtubule-binding KMN protein network.

PMID:
23258294
PMCID:
PMC3762224
DOI:
10.1038/nrm3494
[Indexed for MEDLINE]
Free PMC Article

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