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Dig Dis. 2012;30(6):574-9. doi: 10.1159/000343069. Epub 2012 Dec 13.

Histopathological diagnosis of early HCC through biopsy: efficacy of Victoria blue and cytokeratin 7 staining.

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1
Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Abstract

OBJECTIVES AND METHODS:

Findings of histological analyses of 2 cases of liver biopsy revealing hypovascular nodules are described.

RESULTS:

Ultrasound examination revealed hypovascular and hypoechoic nodules (8 mm in diameter) in segment 1 (case 1) and (8 mm) in segment 8 (case 2). The nodules were detected by only Gd-EOB-DTPA-enhanced MRI. Hematoxylin and eosin staining of ultrasound-guided biopsy of the nodules revealed slight hypercellularity without the features of early hepatocellular carcinoma (HCC) such as cell atypia, fatty change and pseudoglandular formation. Early HCC was suspected; however, Victoria blue staining disclosed terminal portal tract invasion, the most important finding of early HCC. Also, cytokeratin 7 staining revealed decreased ductular reaction compatible with early HCC. Taken together, these histological analyses confirmed the two nodules to be early HCC.

CONCLUSION:

Based on the criteria of the International Consensus Group, the two nodules were diagnosed as early HCC through biopsy.

PMID:
23258097
DOI:
10.1159/000343069
[Indexed for MEDLINE]

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