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Epigenetics. 2013 Jan;8(1):16-22. doi: 10.4161/epi.23331. Epub 2012 Dec 20.

G9a, a multipotent regulator of gene expression.

Author information

1
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Abstract

Lysine methylation of histone and non-histone substrates by the methyltransferase G9a is mostly associated with transcriptional repression. Recent studies, however, have highlighted its role as an activator of gene expression through mechanisms that are independent of its methyltransferase activity. Here we review the growing repertoire of molecular mechanisms and substrates through which G9a regulates gene expression. We also discuss emerging evidence for its wide-ranging functions in development, pluripotency, cellular differentiation and cell cycle regulation that underscore the complexity of its functions. The deregulated expression of G9a in cancers and other human pathologies suggests that it may be a viable therapeutic target in various diseases.

KEYWORDS:

cancer; chromatin modifier; differentiation; gene expression; histones; methylation; transcription; transcription factors

PMID:
23257913
PMCID:
PMC3549875
DOI:
10.4161/epi.23331
[Indexed for MEDLINE]
Free PMC Article
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