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BMC Biol. 2012 Dec 19;10:102. doi: 10.1186/1741-7007-10-102.

Cilia, calcium and the basis of left-right asymmetry.

Author information

1
Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire, OX11 0RD, UK. d.norris@har.mrc.ac.uk

Abstract

The clockwise rotation of cilia in the developing mammalian embryo drives a leftward flow of liquid; this genetically regulated biophysical force specifies left-right asymmetry of the mammalian body. How leftward flow is interpreted and information propagated to other tissues is the subject of debate. Four recent papers have shed fresh light on the possible mechanisms.

PMID:
23256866
PMCID:
PMC3527145
DOI:
10.1186/1741-7007-10-102
[Indexed for MEDLINE]
Free PMC Article

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