Format

Send to

Choose Destination
Nanomedicine (Lond). 2013 Jan;8(1):123-43. doi: 10.2217/nnm.12.185.

Nanoparticles for imaging and treating brain cancer.

Author information

1
Departments of Biomedical Engineering & Radiology, Case Western Reserve University, Cleveland, OH 44106, USA.

Abstract

Brain cancer tumors cause disruption of the selective properties of vascular endothelia, even causing disruptions in the very selective blood-brain barrier, which are collectively referred to as the blood-brain-tumor barrier. Nanoparticles (NPs) have previously shown great promise in taking advantage of this increased vascular permeability in other cancers, which results in increased accumulation in these cancers over time due to the accompanying loss of an effective lymph system. NPs have therefore attracted increased attention for treating brain cancer. While this research is just beginning, there have been many successes demonstrated thus far in both the laboratory and clinical setting. This review serves to present the reader with an overview of NPs for treating brain cancer and to provide an outlook on what may come in the future. For NPs, just like the blood-brain-tumor barrier, the future is wide open.

PMID:
23256496
PMCID:
PMC3564670
DOI:
10.2217/nnm.12.185
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Atypon Icon for PubMed Central
Loading ...
Support Center