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Quant Imaging Med Surg. 2012 Sep;2(3):177-87. doi: 10.3978/j.issn.2223-4292.2012.09.04.

Near infrared fluorescence for image-guided surgery.

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1
Department of Biomedical Engineering, Center for Spatial Systems Biomedicine, Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.

Abstract

Near infrared (NIR) image-guided surgery holds great promise for improved surgical outcomes. A number of NIR image-guided surgical systems are currently in preclinical and clinical development with a few approved for limited clinical use. In order to wield the full power of NIR image-guided surgery, clinically available tissue and disease specific NIR fluorophores with high signal to background ratio are necessary. In the current review, the status of NIR image-guided surgery is discussed along with the desired chemical and biological properties of NIR fluorophores. Lastly, tissue and disease targeting strategies for NIR fluorophores are reviewed.

KEYWORDS:

Near infrared (NIR); image-guided surgery

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