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J Korean Med Sci. 2012 Dec;27(12):1604-6. doi: 10.3346/jkms.2012.27.12.1604. Epub 2012 Dec 7.

Recalcitrant cutaneous ulcer of comorbid patient treated with platelet rich plasma: a case report.

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Department of Dermatology, Korea University College of Medicine, Seoul, Korea.


The platelet-rich plasma (PRP) has been advocated as a way to introduce increased concentrations of growth factors and other bioactive molecules to injured tissues in an attempt to optimize the local healing environment. A 94-yr-old woman with various comorbidities presented with a two-week history of severe cutaneous ulcer on the left dorsum of foot. It was caused by recurrent mechanical trauma and did not respond to several wound debridement and simple dressings. However, after she was completed on seven times of autologous PRP treatments, we observed complete healing of the skin lesion within 3 months. Herein, we report a case of recalcitrant cutaneous ulcer with various comorbidities and discuss about the promising possibility of autologous PRP as an effective alternative therapeutic modality.


Aged; Diabetes; Platelet Rich Plasma (PRP); Refractory Ulcer

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