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Lab Hematol. 2012 Dec;18(4):30-41. doi: 10.1532/LH96.11003.

Biology and bioinformatics of myeloma cell.

Author information

1
Department of Hematology and Blood Banking, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran. abroun@modares.ac.ir

Abstract

Multiple myeloma (MM) is a plasma cell disorder that occurs in about 10% of all hematologic cancers. The majority of patients (99%) are over 50 years of age when diagnosed. In the bone marrow (BM), stromal and hematopoietic stem cells (HSCs) are responsible for the production of blood cells. Therefore any destruction or/and changes within the BM undesirably impacts a wide range of hematopoiesis, causing diseases and influencing patient survival. In order to establish an effective therapeutic strategy, recognition of the biology and evaluation of bioinformatics models for myeloma cells are necessary to assist in determining suitable methods to cure or prevent disease complications in patients. This review presents the evaluation of molecular and cellular aspects of MM such as genetic translocation, genetic analysis, cell surface marker, transcription factors, and chemokine signaling pathways. It also briefly reviews some of the mechanisms involved in MM in order to develop a better understanding for use in future studies.

PMID:
23253865
DOI:
10.1532/LH96.11003
[Indexed for MEDLINE]
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