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Lab Hematol. 2012 Dec;18(4):22-6. doi: 10.1532/LH96.12006.

Platelet hyperreactivity: report of a case with catastrophic arterial thrombosis in a child.

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1
Department of Pathology, The Ohio State University, Columbus, OH, USA.

Abstract

Platelet hyperreactivity is an important but under-recognized cause of idiopathic arterial thrombosis. We describe a case of arterial thrombosis in a previously healthy 12-year-old girl after minor trauma to the knee, resulting in lower extremity amputation. Family history was positive for arterial and venous thrombosis, but an extensive work-up for the usual inherited thrombophilia risk factors was negative. The patient was eventually diagnosed with platelet hyperreactivity and remains on life-long antiplatelet therapy.Consideration of platelet hyperreactivity in the evaluation of unusual arterial thrombotic events allows for targeted therapy, potential avoidance of future events, and timely screening of family members.

PMID:
23253863
DOI:
10.1532/LH96.12006
[Indexed for MEDLINE]
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