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J Agric Food Chem. 2013 Jan 30;61(4):913-9. doi: 10.1021/jf300359a. Epub 2013 Jan 17.

Dietary intake of melatonin from tropical fruit altered urinary excretion of 6-sulfatoxymelatonin in healthy volunteers.

Author information

1
Faculty of Pharmaceutical Sciences and Melatonin Research Group, Khon Kaen University, Khon Kaen 40002, Thailand. pnutja@kku.ac.th

Abstract

This study assessed the melatonin content of six tropical fruits and examined whether human consumption could contribute to dietary melatonin as measured by 6-sulfatoxymelatonin (aMT6-s, a marker of circulating melatonin in the body). Melatonin was extracted using methanol and analyzed by high-performance liquid chromatography. In a clinical crossover study, 30 healthy volunteers consumed selected fruits one at a time, with a 1week wash-out period between fruits, until completing all six fruits. Most fruits had moderate melatonin content. Significant increases in urine aMT6-s concentrations were seen after the consumption of pineapple (266%, p = 0.004), banana (180%, p = 0.001), and orange (47%, p = 0.007). The need to analyze melatonin both in fruit and as in vivo uptake was demonstrated. Further study is warranted regarding the clinical effect of fruit consumption in people with age-related melatonin reduction problems such as sleeplessness and illnesses involving oxidative damage.

PMID:
23252791
DOI:
10.1021/jf300359a
[Indexed for MEDLINE]

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