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Future Microbiol. 2013 Jan;8(1):107-21. doi: 10.2217/fmb.12.122.

Library screening and receptor-directed targeting of gammaretroviral vectors.

Author information

1
University of Medicine & Dentistry of NJ-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA.

Abstract

Gene- and cell-based therapies hold great potential for the advancement of the personalized medicine movement. Gene therapy vectors have made dramatic leaps forward since their inception. Retroviral-based vectors were the first to gain clinical attention and still offer the best hope for the long-term correction of many disorders. The fear of nonspecific transduction makes targeting a necessary feature for most clinical applications. However, this remains a difficult feature to optimize, with specificity often coming at the expense of efficiency. The aim of this article is to discuss the various methods employed to retarget retroviral entry. Our focus will lie on the modification of gammaretroviral envelope proteins with an in-depth discussion of the creation and screening of envelope libraries.

PMID:
23252496
PMCID:
PMC3564632
DOI:
10.2217/fmb.12.122
[Indexed for MEDLINE]
Free PMC Article

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