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Ther Adv Chronic Dis. 2011 Mar;2(2):87-99. doi: 10.1177/2040622310389507.

Current and emerging therapies for the management of functional gastrointestinal disorders.

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Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland and Department of Medicine, Clinical Sciences Building, Cork University Hospital, Cork, Ireland.


The functional gastrointestinal disorders are common disorders that are associated with significant quality-of-life impairment and considerable economic burden on the healthcare system. They are frequently associated with a comorbid psychiatric condition; this, together with a striking lack of effective pharmacological therapies, means they represent a considerable therapeutic challenge to the treating physician. In this overview, we examine the evidence to support the use of agents currently used in the management of the more common functional gastrointestinal disorders and review emerging therapies.


antibiotics; antidepressants; cognitive behavioural therapy; functional dyspepsia; functional gastrointestinal disorders; functional heartburn; irritable bowel syndrome; probiotics; serotonin

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