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Psychiatry Investig. 2012 Dec;9(4):384-90. doi: 10.4306/pi.2012.9.4.384. Epub 2012 Nov 12.

Effect of methylphenidate on sleep parameters in children with ADHD.

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1
Department of Neuropsychiatry, Yeungnam University College of Medicine, Daegu, Republic of Korea.

Abstract

OBJECTIVE:

The primary aim of this study was to investigate the acute impact of methylphenidate (MPH) on sleep parameters in attention-deficit/hyperactivity disorder (ADHD) children. The second aim was to investigate the different effects of intermediate- and longacting MPH on sleep parameters. The third aim was to test the different effects of dose and age on sleep parameters.

METHODS:

Ninety-three ADHD children were enrolled and randomized to two different MPH preparations. Baseline and daily sleep diaries were evaluated for four weeks after taking medication. Weekday and weekend bedtimes, wake-up times, sleep latencies and total sleep times were compared by weeks.

RESULTS:

After taking MPH, there was a significant delay in bedtimes and a significant reduction of total sleep time (TST) both on weekdays and at weekends. There was also a significant delay in wake-up time on weekdays. However, the difference was applied to younger age group children only. There was no difference in changes of TST between metadate-CD and OROS-MPH. There also was no difference in changes of TST with different doses of MPH.

CONCLUSION:

MPH had negative impacts on sleep among young ADHD children, but different preparations and doses did not affect the result.

KEYWORDS:

ADHD; Children; Metadate-CD; Methylphenidate; OROS-MPH

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