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Cold Spring Harb Perspect Biol. 2013 Feb 1;5(2). pii: a013342. doi: 10.1101/cshperspect.a013342.

Protein translocation across the rough endoplasmic reticulum.

Author information

1
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605-2324, USA.

Abstract

The rough endoplasmic reticulum is a major site of protein biosynthesis in all eukaryotic cells, serving as the entry point for the secretory pathway and as the initial integration site for the majority of cellular integral membrane proteins. The core components of the protein translocation machinery have been identified, and high-resolution structures of the targeting components and the transport channel have been obtained. Research in this area is now focused on obtaining a better understanding of the molecular mechanism of protein translocation and membrane protein integration.

PMID:
23251026
PMCID:
PMC3552503
DOI:
10.1101/cshperspect.a013342
[Indexed for MEDLINE]
Free PMC Article

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