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Dtsch Med Wochenschr. 2013 Jan;138(1-2):39-42. doi: 10.1055/s-0032-1327368. Epub 2012 Dec 18.

[Losmapimod: a novel drug against cardiovascular diseases?].

[Article in German]

Author information

1
Abteilung Pharmakologie, Universitätsmedizin Göttingen, Göttingen.

Abstract

Losmapimod is a promising new agent against cardiovascular diseases. This drug works by inhibiting p38 MAP kinases, which play an important role in the development of atherosclerosis and heart failure caused by ischemic conditions. Preclinical data from in vitro and in vivo studies suggest a protective role of pharmacological p38 inhibition with regard to the development of cardiovascular diseases. This article evaluates the therapeutic potential of this new pharmacological approach and discusses the current clinical data on Losmapimod.

PMID:
23250695
DOI:
10.1055/s-0032-1327368
[Indexed for MEDLINE]
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