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Nat Commun. 2012;3:1291. doi: 10.1038/ncomms2276.

Elevated oncofoetal miR-17-5p expression regulates colorectal cancer progression by repressing its target gene P130.

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1
Department of General Surgery, Tenth People's Hospital affiliated to Tongji University, 301 Yanchang Road, Shanghai 200072, China.

Abstract

MicroRNAs (miRNAs) are essential for regulating normal embryonic development and carcinogenesis. Here we report that miR-17-5p, an oncofoetal miRNA, is a key regulator of colorectal cancer progression. We show that miR-17-5p is an oncogenic miRNA that regulates tumorigenesis and progression by targeting the gene encoding P130 and subsequently activating the Wnt/β-catenin pathway. Using specimens from two large cohorts of colorectal cancer patients, we found that patients whose tumours had high miR-17-5p expression had shorter overall survival rates but showed a better response to adjuvant chemotherapy than did patients whose tumours had low miRNA expression. We also observed a strong inverse correlation between miR-17-5p and P130 expression. The current findings suggest that miR-17-5p is a crucial determinant of colorectal cancer progression.

PMID:
23250421
DOI:
10.1038/ncomms2276
[Indexed for MEDLINE]
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