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Int J Environ Res Public Health. 2012 Dec 18;9(12):4744-59. doi: 10.3390/ijerph9124744.

Second malignant neoplasms following radiotherapy.

Author information

1
Department of Radiation Oncology, Henry Ford Hospital, Detroit, MI 48202, USA. skumar4@hfhs.org

Abstract

More than half of all cancer patients receive radiotherapy as a part of their treatment. With the increasing number of long-term cancer survivors, there is a growing concern about the risk of radiation induced second malignant neoplasm [SMN]. This risk appears to be highest for survivors of childhood cancers. The exact mechanism and dose-response relationship for radiation induced malignancy is not well understood, however, there have been growing efforts to develop strategies for the prevention and mitigation of radiation induced cancers. This review article focuses on the incidence, etiology, and risk factors for SMN in various organs after radiotherapy.

PMID:
23249860
PMCID:
PMC3546788
DOI:
10.3390/ijerph9124744
[Indexed for MEDLINE]
Free PMC Article
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