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Am J Trop Med Hyg. 2013 Feb;88(2):325-8. doi: 10.4269/ajtmh.2012.12-0297. Epub 2012 Dec 18.

Genetic variability in platelet integrin α2β1 density: possible contributor to Plasmodium vivax-induced severe thrombocytopenia.

Author information

1
Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil. fernanda@cpqrr.fiocruz.br

Abstract

Understanding the pathogenesis of Plasmodium vivax malaria is challenging. We hypothesized that susceptibility to P. vivax-induced thrombocytopenia could be associated with polymorphisms on relevant platelet membrane integrins: integrin α2 (C807T), and integrin β3 (T1565C). Although β3 polymorphism was not related with P. vivax malaria, α2 807T carriers, which show high levels of integrin α2β1, had a higher probability for severe thrombocytopenia than wild-type carriers. This evidence of the association of integrin polymorphism and P. vivax morbidity was further demonstrated by a moderate but significant correlation between clinical disease and surface levels of the integrin α2β1.

PMID:
23249684
PMCID:
PMC3583325
DOI:
10.4269/ajtmh.2012.12-0297
[Indexed for MEDLINE]
Free PMC Article

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