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Dev Neurorehabil. 2013;16(1):58-66. doi: 10.3109/17518423.2012.704414.

Parental reports on early language and motor milestones in fragile X syndrome with and without autism spectrum disorders.

Author information

1
Clinical Trials Center, Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Abstract

OBJECTIVE:

This study examined features of early language and motor milestones in children with fragile X syndrome (FXS) and contrasted these features with a diagnosis of Autism Spectrum Disorder (ASD) later in life in these children.

METHODS:

We retrospectively examined parental report of age of onset for walking and first words for primarily boys with FXS, both with ASD (FXS + ASD) and FXS-only. The diagnosis of ASD was established by DSM-IV criteria, which were complemented by the ADOS. The age of onset was analyzed as a continuous and categorical variable, which were compared to the upper limit of typically developing children.

RESULTS:

Individuals with FXS-only are more delayed in the onset of first words than first walks. The finding represents a pattern suggesting a continuum as robustly demonstrated in individuals with FXS + ASD vs. FXS-only.

CONCLUSION:

Our results support validity of FXS + ASD co-morbidity as a distinct phenotype in individuals with FXS.

PMID:
23249372
DOI:
10.3109/17518423.2012.704414
[Indexed for MEDLINE]

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