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Open Respir Med J. 2012;6:135-8. doi: 10.2174/1874306401206010135. Epub 2012 Nov 30.

Reduction of Raf Kinase Inhibitor Protein Expression is Associated with Lymph Node Metastasis in Resectable Non-small Cell Lung Cancer.

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1
Department of Infectious Disease, Xiangya Hospital, Central South University, Xiangya Road, Changsha, China.

Abstract

INTRODUCTION:

Raf kinase inhibitor protein (RKIP) had been identified as one of prognostic indictor in various malignant diseases. Association of RKIP expression and the clinical-pathological features were not investigated in patients with resectable non-small cell lung cancer (NSCLC).

MATERIALS AND METHODOLOGY:

159 sectioned samples from surgical NSCLC patients were investigated by immunohistochemistry in order to reveal the associations between RKIP expression and clinical-pathologic features.

RESULTS:

Statistically, Lower RKIP expression level was found in the group with higher N stage (P<0.01) and higher TNM stage (P<0.05). No significant correlation was observed between RKIP expressions and histologic type (P>0.05) and tumor size (P>0.05).

CONCLUSIONS:

Down expression level of RKIP was found relating to lymph node metastasis in resectable NSCLC patients in this study.

KEYWORDS:

Raf kinase inhibitor protein; lymph node metastasis.; non-small cell lung cancer

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