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Front Immunol. 2012 Dec 11;3:373. doi: 10.3389/fimmu.2012.00373. eCollection 2012.

B cell subsets in atherosclerosis.

Author information

1
Department of Pathology, University of Virginia Charlottesville, VA, USA ; Cardiovascular Research Center, University of Virginia Health System Charlottesville, VA, USA.

Abstract

Atherosclerosis, the underlying cause of heart attacks and strokes, is a chronic inflammatory disease of the artery wall. Immune cells, including lymphocytes modulate atherosclerotic lesion development through interconnected mechanisms. Elegant studies over the past decades have begun to unravel a role for B cells in atherosclerosis. Recent findings provide evidence that B cell effects on atherosclerosis may be subset-dependent. B-1a B cells have been reported to protect from atherosclerosis by secretion of natural IgM antibodies. Conventional B-2 B cells can promote atherosclerosis through less clearly defined mechanism that may involve CD4 T cells. Yet, there may be other populations of B cells within these subsets with different phenotypes altering their impact on atherosclerosis. Additionally, the role of B cell subsets in atherosclerosis may depend on their environmental niche and/or the stage of atherogenesis. This review will highlight key findings in the evolving field of B cells and atherosclerosis and touch on the potential and importance of translating these findings to human disease.

KEYWORDS:

B cell; IgM; atherosclerosis; cytokines; lipids

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