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Indian J Pharmacol. 2012 Nov-Dec;44(6):683-7. doi: 10.4103/0253-7613.103242.

Protective effect of methanolic extract of Garcinia indica fruits in 6-OHDA rat model of Parkinson's disease.

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1
Department of Pharmacology and Toxicology, NIPER, Guwahati, Assam, India.

Abstract

CONTEXT:

Several studies have reported that antioxidants play an important role in Parkinson's disease (PD). Garcinia indica extract is a natural antioxidant, the present study was undertaken to evaluate the neuroprotective effect of methanolic extract of Garcinia indica (GIM) against 6-hydroxydopamine (6-OHDA) neurotoxicity for striatal dopaminergic neurons in the rat.

MATERIALS AND METHODS:

Thirty adult Wistar rats were randomly divided into five groups namely control, 6-OHDA model, and GIM (100, 200, and 400 mg/kg body weight suspended in one ml of 0.1% carboxymethyl cellulose). The treatment was started three days before surgery and continued for next 14 days. The surgery was done on third day in all groups for administration of 6-OHDA into the right striatum and right substantia nigra, whereas control group injected with 6-OHDA vehicle. Various behavior and biochemical tests (Apomorphine-induced rotational behavior, Stepping test, Initiation time, Postural balance test, and Disengage time) were used to evaluate the neuroprotective effect of GIM. One-way analysis of variance (ANOVA) followed by Dunnett's test was used to compare inter-group differences. P<0.05 was considered as statistically significant.

RESULTS:

GIM had significant (P<0.05, P<0.01) preventive effect in biochemical tests, i.e., dopamine and its metabolites measurement and in various behavior tests, i.e., apomorphine-induced rotational behavior, stepping test, initiation time, postural balance test, and disengage time as compared to 6-OHDA-treated rats.

CONCLUSIONS:

Our results demonstrated that GIM acted as an effective neuroprotective agent for striatal dopaminergic neurons in 6-OHDA lesioned rat model of PD.

KEYWORDS:

6-OHDA; Garcinia indica; Parkinson's disease

PMID:
23248394
PMCID:
PMC3523492
DOI:
10.4103/0253-7613.103242
[Indexed for MEDLINE]
Free PMC Article
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