Format

Send to

Choose Destination
See comment in PubMed Commons below
Cell Res. 2013 Jan;23(1):49-69. doi: 10.1038/cr.2012.175. Epub 2012 Dec 18.

Embryonic stem cell and induced pluripotent stem cell: an epigenetic perspective.

Author information

1
Howard Hughes Medical Institute, Harvard Medical School, WAB-149G, 200 Longwood Avenue, Boston, MA 02115, USA.

Abstract

Pluripotent stem cells, like embryonic stem cells (ESCs), have specialized epigenetic landscapes, which are important for pluripotency maintenance. Transcription factor-mediated generation of induced pluripotent stem cells (iPSCs) requires global change of somatic cell epigenetic status into an ESC-like state. Accumulating evidence indicates that epigenetic mechanisms not only play important roles in the iPSC generation process, but also affect the properties of reprogrammed iPSCs. Understanding the roles of various epigenetic factors in iPSC generation contributes to our knowledge of the reprogramming mechanisms.

PMID:
23247625
PMCID:
PMC3541668
DOI:
10.1038/cr.2012.175
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Support Center